When patients are first diagnosed with an autoimmune condition, a common initial response is confusion. “I like my thyroid (or insert appropriate organ) – why doesn’t my immune system?” The cause of this internal power struggle remains unknown. Current theories point to viral infections as the etiology. What is even more worrisome is that once you have one autoimmune disease your likelihood of developing another one increases exponentially. Celiac and Hashimoto’s Thyroiditis go hand in hand. More than eighty different diseases are classified as autoimmune conditions. In conventional medicine, treatment has been limited to immunosuppressant drugs. Alternative medicine offers more options with supportive treatments such as acupuncture, nutritional support, IV therapies, and herbal medicine. A new use for an old drug offers another powerful option that may reverse the autoimmune process. This is low dose naltrexone therapy.

Since 1980, therapies developed by a neurologist may cure or at least slow the process of autoimmune conditions. Neurologist Dr. Bernard Bihari started using low dose naltrexone on his Multiple Sclerosis patients in New York City. His research showed that low dose naltrexone stopped cell death of oligodendrocytes which produce myelin, prevented the inhibition of glutamate transporters, prevented excitatory neurotoxicity on neurons, and reduced inflammation in neurons. In short, MS, which is a progressive disease process that is characterized by demyelination of neurons, was being reversed. Low dose naltrexone has also been given for some cancers and HIV with promising results. At high doses, naltrexone is conventionally used for opiate drug addiction. It is classified as an opiate agonist. The dosage for addiction is 50-300mg a day.

The cells of the immune system have several types of opiod receptors and naltrexone in low doses blocks mu opiod receptor decreasing the immune systems responsiveness to antigens. The balance between delta/mu receptors lead to competent immune system that recognizes self from non-self. Naltrexone increases Th1 and decrease Th2 cytokine production, decreases IL-4 production and increase IL-2 and interferon gamma levels. Low Th1 levels increase the production of auto reactive T lymphocytes and of auto antibodies. What this means is naltrexone gets your immune system to stop seeing you as the enemy.

Low dose naltrexone therapy has been successfully used to reverse the autoimmune disease process in Hashimoto’s Thyroiditis, Lupus, Rheumatoid Arthritis, and Multiple Sclerosis. Patients typically notice symptomatic improvement within a month. After 3-6 months of treatment, autoimmune antibodies are considerably lower and sometimes undetectable. Treatment is 1.5mg to 3mg of naltrexone taken before bed. At this low dose naltrexone has no known side effects. In conjunction with supportive therapies, low dose naltrexone is a powerful weapon to combat autoimmune diseases.